Piperine is a solid and is essentially insoluble in water. Tasteless at first, it subsequently leaves a burning aftertaste. Piperine belongs to the vanilloid family of compounds, a family that also includes capsaicin, the pungent substance in hot chili peppers.
Piper nigrum and Piper longum have been used in traditional Ayurvedic medicine for the treatment of various diseases. One such preparation - consisting of black pepper, long pepper and ginger - is known by the Sanskrit name trikatu. Another formulation, known by the Sanskrit name pippali, involves long pepper. It is believed that piperine is a major bioactive substance of these Ayurvedic remedies.
Pepper also figures greatly in traditional Chinese medicine. Black pepper has been used to treat seizures. A derivative of piperine, antiepilepsirine, has also been used for seizure disorders by the Chinese.
(Source: PDR Health, http://www.pdrhealth.com)
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